Article

Genetic Reinstatement of RIG-I in Chickens Reveals Insights into Avian Immune Evolution and Influenza Interaction

2023-11-02

Abstract excerpt

Retinoic acid-inducible gene I ( RIG-I ) activates mitochondrial antiviral signaling proteins, initiating the antiviral response. RIG-I and RNF135 , a ubiquitin ligase regulator, are missing in domestic chickens but conserved in mallard ducks. The chickens’ RIG-I loss was long believed to be linked to increased avian influenza susceptibility. We reinstated both genes in chickens and examined their susceptibili...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9421edc1-6a5d-5bdb-9f44-b205668fd807
DOI: 10.1101/2023.11.01.564710

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Reinstatement of RIG-I in Chickens Reveals Insights into Avian Immune Evolution and Influenza InteractionDOI 10.1101/2023.11.01.564710Read

Avian Influenza NS1 Proteins Inhibit Human, but Not Duck, RIG-I Ubiquitination and Interferon SignalingSemantic proximity Read

Characterization of Chicken Mda5 Activity: Regulation of IFN-β in the Absence of RIG-I FunctionalitySemantic proximity Read

Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and ChickensSemantic proximity Read

Modelling molecular differences in the innate immune system responses of chickens and ducks to highly pathogenic avian influenza virusSemantic proximity Read

Innate sensing of viruses by pattern recognition receptors in birdsSemantic proximity Read

Ancient Origins of Vertebrate-Specific Innate Antiviral ImmunitySemantic proximity Read

A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistanceSemantic proximity Read

RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous DucksSemantic proximity Read

Molecular characterization of RIGI, TLR7 and TLR3 as immune response gene of indigenous ducks in response to Avian influenzaSemantic proximity Read

A chicken interferon stimulated gene screen reveals limited genes restricting influenza replicationSemantic proximity Read

Role of RIGI, MDA5 and interferon alpha of duck in Duck Plague infection – a novel reportSemantic proximity Read

Chicken DDX1 Acts as an RNA Sensor to Mediate IFN-β Signaling Pathway Activation in Antiviral Innate ImmunitySemantic proximity Read