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Article

Polymorphism -2604G>A variants in TLR4 promoter are associated with different gene expression level in peripheral blood of atherosclerotic patients.

Journal of human genetics - 1 Dec 2013

Ferronato Silvia, Gomez-Lira Macarena, Menegazzi Marta, Diani Erica, Olivato Silvia, Sartori Marianna, Scuro Alberto, Malerba Giovanni, Pignatti Pier Franco, Romanelli Maria Grazia, Mazzucco Sara

Abstract excerpt

Toll-like receptor-4 (TLR4) is a primary receptor of the innate immune reaction and compelling evidence demonstrates its involvement in the pathogenesis of atherosclerosis and stroke. TLR4 is constitutively expressed on monocytes and endothelial cells; it is highly expressed in atherosclerotic plaques and in peripheral blood of patients after ischemic stroke. Polymorphisms in the promoter region that alter the...

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PMID: 24108365
DOI: 10.1038/jhg.2013.98

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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