Article
Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study.
Annals of the New York Academy of Sciences - 1 Apr 2007
Trompet S, Pons D, DE Craen A J M, Slagboom P, Shepherd J, Blauw G J, Murphy M B, Cobbe S M, Bollen E L E M, Buckley B M, Ford I, Hyland M, Gaw A, Macfarlane P W, Packard C J, Norrie J, Perry I J, Stott D J, Sweeney B J, Twomey C, Westendorp R G J, Jukema J W
Abstract excerpt
Proinflammatory cytokines, like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), are implicated in the development of atherosclerosis. The role of anti-inflammatory cytokines, like IL-10, is largely unknown. We investigated the association of four single nucleotide polymorphisms (SNPs) in the promoter region of the IL-10 gene (4259AG, -1082GA, -592CA, and -2849GA), with coronary and...
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