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Article

TLR4 polymorphisms affect stroke risk and inflammatory response in Chinese ischemic stroke patients.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Jan 2018

Gu Lian, Huang Jingyan, Liang Baoyun, Chen Qing, Xie Juanjuan, Yang Junwei, Yan Yan, Tang Qianli

Abstract excerpt

This study aimed to evaluate the association of the toll-like receptor 4 (TLR4) polymorphisms rs1927914, rs10759932, and rs11536889 with susceptibility to ischemic stroke (IS) and the serum levels of inflammatory cytokines. A total of 816 IS patients and 816 control subjects were genotyped using Sequenom MassARRAY technology. The serum levels of interleukin 1 beta (IL-1β), interleukin 6 (IL-6), interleukin 8...

Topics

Aged
Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Brain Ischemia

Case-Control Studies

China

Female

Gene Frequency

Genetic Predisposition to Disease

Genotype

Humans

Inflammation

Inflammation Mediators

Male

Middle Aged

Polymorphism, Single Nucleotide

Stroke

Toll-Like Receptor 4

Source

Identifiers

PMID: 29075930
DOI: 10.1007/s10072-017-3151-y

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29075930-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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