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Article

Amino acid composition of proteins reduces deleterious impact of mutations.

Scientific reports - 10 Oct 2013

Hormoz Sahand

Abstract excerpt

The evolutionary origin of amino acid occurrence frequencies in proteins (composition) is not yet fully understood. We suggest that protein composition works alongside the genetic code to minimize impact of mutations on protein structure. First, we propose a novel method for estimating thermodynamic stability of proteins whose sequence is constrained to a fixed composition. Second, we quantify the average...

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Identifiers

PMID: 24108121
DOI: 10.1038/srep02919
PMCID: PMC3794375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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