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Article

Functional analysis of purine nucleoside phosphorylase as a key enzyme in ribavirin metabolism.

Drug metabolism and pharmacokinetics - 1 Jan 2014

Furihata Tomomi, Kishida Satoshi, Sugiura Hanae, Kamiichi Atsuko, Iikura Minami, Chiba Kan

Abstract excerpt

Ribavirin is a purine nucleoside analogue that possesses potent anti-hepatitis C virus activity, and it has long been considered likely that ribavirin undergoes a first-pass metabolism at the small intestine. Although purine nucleoside phosphorylase (PNP) is assumed to be involved in this metabol...

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Identifiers

PMID: 24107682
DOI: 10.2133/dmpk.dmpk-13-nt-065

Genes

PNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24107682-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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