Article
Functional analysis of purine nucleoside phosphorylase as a key enzyme in ribavirin metabolism.
Drug metabolism and pharmacokinetics - 1 Jan 2014
Furihata Tomomi, Kishida Satoshi, Sugiura Hanae, Kamiichi Atsuko, Iikura Minami, Chiba Kan
Abstract excerpt
Ribavirin is a purine nucleoside analogue that possesses potent anti-hepatitis C virus activity, and it has long been considered likely that ribavirin undergoes a first-pass metabolism at the small intestine. Although purine nucleoside phosphorylase (PNP) is assumed to be involved in this metabolism, this has not been conclusively demonstrated. Furthermore, no pharmacogenomic studies related to PNP-mediated...
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