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Article

A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein.

Molecular pharmaceutics - 1 Jan 2000

Kim Insook, Song Xueqin, Vig Balvinder S, Mittal Sachin, Shin Ho-Chul, Lorenzi Philip J, Amidon Gordon L

Abstract excerpt

Biphenyl hydrolase-like protein (BPHL, NCBI accession number NP_004323) is a novel human serine hydrolase recently identified as a human valacyclovirase, catalyzing the hydrolytic activation of the antiviral prodrugs valacyclovir and valganciclovir. The substrate specificity of BPHL was investigated with a series of amino acid ester prodrugs of the therapeutic nucleoside analogues: acyclovir, zidovudine,...

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Source

Identifiers

PMID: 15832508
DOI: 10.1021/mp0499757

Genes

BPHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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