A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein.

doi:10.1021/mp0499757

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Article

A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein.

Molecular pharmaceutics - 1 Jan 2000

Kim Insook, Song Xueqin, Vig Balvinder S, Mittal Sachin, Shin Ho-Chul, Lorenzi Philip J, Amidon Gordon L

Abstract excerpt

Biphenyl hydrolase-like protein (BPHL, NCBI accession number NP_004323) is a novel human serine hydrolase recently identified as a human valacyclovirase, catalyzing the hydrolytic activation of the antiviral prodrugs valacyclovir and valganciclovir. The substrate specificity of BPHL was investigated with a series of amino acid ester prodrugs of the therapeutic nucleoside analogues: acyclovir, zidovudine,...

Topics

Acyclovir
Amino Acid Sequence
Antiviral Agents
Carboxylic Ester Hydrolases
Cloning, Molecular
Drug Design
Enzyme Activation
Escherichia coli
Ganciclovir
Genetic Variation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Molecular Sequence Data

Prodrugs

Recombinant Fusion Proteins

Sequence Alignment

Sequence Homology, Amino Acid

Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 15832508
DOI: 10.1021/mp0499757

Genes

BPHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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