Article
Frequency of uridine monophosphate synthase Gly(213)Ala polymorphism in Caucasian gastrointestinal cancer patients and healthy subjects, investigated by means of new, rapid genotyping assays.
Genetic testing and molecular biomarkers - 1 Oct 2011
Gusella Milena, Bertolaso Laura, Bolzonella Caterina, Pasini Felice, Padrini Roberto
Abstract excerpt
AIMS: Uridine monophosphate synthase (UMPS) is a fundamental enzyme in pyrimidine synthesis. A single-nucleotide polymorphism, a G-C transversion at the 638th nucleotide, was demonstrated to increase UMPS activity and suggested to have clinical effects. The aims of this study were to set up simple genotyping methods and investigate the UMPS 638G>C polymorphism in the Caucasian population. RESULTS: Two hundred...
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