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Article

The <i>Sall3</i> locus is an epigenetic hotspot of aberrant DNA methylation associated with placentomegaly of cloned mice

1 Mar 2004

Abstract excerpt

DNA methylation controls various developmental processes by silencing, switching and stabilizing genes as well as remodeling chromatin. Among various symptoms in cloned animals, placental hypertrophy is commonly observed. We identified the Spalt-like gene3 (Sall3) locus as a hypermethylated region in the placental genome of cloned mice. The Sall3 locus has a CpG island containing a tissue-dependent differentially...

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PMID: 15005712
DOI: 10.1111/j.1356-9597.2004.00720.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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