Article
Genotype variant associated with add-on memantine in bipolar II disorder.
The international journal of neuropsychopharmacology - 1 Feb 2014
Lee Sheng-Yu, Chen Shiou-Lan, Chang Yun-Hsuan, Chen Shih-Heng, Chu Chun-Hsieh, Huang San-Yuan, Tzeng Nian-Sheng, Wang Chen-Lin, Wang Liang-Jen, Lee I Hui, Yeh Tzung Lieh, Yang Yen Kuang, Hong Jau-Shyong, Lu Ru-Band
Abstract excerpt
Memantine is a non-competitive N-methyl-d-asparate (NMDA) receptor antagonist with a mood-stabilizing effect. We investigated whether using valproic acid (VPA) plus add-on memantine to treat bipolar II disorder (BP-II) is more effective than using VPA alone (VPA + Pbo). We also evaluated, in BP-II patients, the association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with treatment...
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