Article
Functional promoter polymorphisms of NFKB1 influence susceptibility to the diffuse type of gastric cancer.
Oncology reports - 1 Dec 2013
Arisawa Tomiyasu, Tahara Tomomitsu, Shiroeda Hisakazu, Yamada Kaho, Nomura Tomoe, Yamada Hideto, Hayashi Ranji, Matsunaga Kazuhiro, Otsuka Toshimi, Nakamura Masakatsu, Shimasaki Takeo, Toshikuni Nobuyuki, Kawada Natsuko, Shibata Tomoyuki
Abstract excerpt
In the present study, we report an association between gastric cancer and polymorphisms in NFKB1 (rs28362941 and rs78696119). We employed the PCR-SSCP method to detect gene polymorphisms in 479 gastric cancer cases and 880 controls. The rs28362941 del/del homozygote was significantly associated with gastric cancer development; in particular it was closely associated with diffuse type gastric cancer. The...
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