Article
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer.
Nature genetics - 1 Jun 2008
Sakamoto Hiromi, Yoshimura Kimio, Saeki Norihisa, Katai Hitoshi, Shimoda Tadakazu, Matsuno Yoshihiro, Saito Daizo, Sugimura Haruhiko, Tanioka Fumihiko, Kato Shunji, Matsukura Norio, Matsuda Noriko, Nakamura Tsuneya, Hyodo Ichinosuke, Nishina Tomohiro, Yasui Wataru, Hirose Hiroshi, Hayashi Matsuhiko, Toshiro Emi, Ohnami Sumiko, Sekine Akihiro, Sato Yasunori, Totsuka Hirohiko, Ando Masataka, Takemura Ryo, Takahashi Yoriko, Ohdaira Minoru, Aoki Kenichi, Honmyo Izumi, Chiku Suenori, Aoyagi Kazuhiko, Sasaki Hiroki, Ohnami Shumpei, Yanagihara Kazuyoshi, Yoon Kyong-Ah, Kook Myeong-Cherl, Lee Yeon-Su, Park Sook Ryun, Kim Chan Gyoo, Choi Il Ju, Yoshida Teruhiko, Nakamura Yusuke, Hirohashi Setsuo
Abstract excerpt
Gastric cancer is classified into intestinal and diffuse types, the latter including a highly malignant form, linitis plastica. A two-stage genome-wide association study (stage 1: 85,576 SNPs on 188 cases and 752 references; stage 2: 2,753 SNPs on 749 cases and 750 controls) in Japan identified a significant association between an intronic SNP (rs2976392) in PSCA (prostate stem cell antigen) and diffuse-type...
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