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Heme oxygenase microsatellite polymorphism, oxidative stress, glycemic control, and complication development in type 2 diabetes patients.

Free radical biology & medicine - 1 Jul 2012

Choi Siu-Wai, Yeung Vincent Tok Fai, Benzie Iris F F

Abstract excerpt

Heme oxygenase-1 (HMOX-1) is activated by oxidative stress, and gene responsiveness is reportedly determined by the number of dinucleotide (GT(n)) repeats in its highly polymorphic promoter region. "Short" (S; GT(n)<25) alleles reportedly associate with higher response, lower oxidative stress, lower risk of type 2 diabetes mellitus (type 2DM), and better glycemic control and outcome, but data are conflicting. We...

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PMID: 22583702
DOI: 10.1016/j.freeradbiomed.2012.04.017

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