Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production.

PloS one - 1 Jan 2012

Verma Deepti, Särndahl Eva, Andersson Henrik, Eriksson Per, Fredrikson Mats, Jönsson Jan-Ingvar, Lerm Maria, Söderkvist Peter

Abstract excerpt

BACKGROUND: The Q705K polymorphism in NLRP3 has been implicated in several chronic inflammatory diseases. In this study we determine the functional role of this commonly occurring polymorphism using an in-vitro system. PRINCIPAL FINDINGS: NLRP3-WT and NLRP3-Q705K were retrovirally transduced into the human monocytic cell line THP-1, followed by the assessment of IL-1β and IL-18 levels in the cell culture...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Caspase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammasomes

Share to Interleukin-18

Share to Interleukin-1beta

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Receptors, Interleukin-1

Share to Transduction, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 22529966
DOI: 10.1371/journal.pone.0034977
PMCID: PMC3328489

Genes

NLRP3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production.PMID 22529966Read ↗

Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome.Semantic proximity Read ↗

A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.Semantic proximity Read ↗

NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.Semantic proximity Read ↗

Functional diversity of <i>NLRP3</i> gain-of-function mutants associated with CAPS autoinflammationSemantic proximity Read ↗

PReS-FINAL-2196: The clinical significance of the Q703K mutation of NLRP3 gene. A multicentric national studySemantic proximity Read ↗

Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation.Semantic proximity Read ↗

A functional inflammasome activation assay differentiates patients with pathogenic NLRP3 mutations and symptomatic patients with low penetrance variants.Semantic proximity Read ↗

Increased Prevalence of NLRP3 Q703K Variant Among Patients With Autoinflammatory Diseases: An International Multicentric Study.Semantic proximity Read ↗

The NLRP3 Inflammasome and Its Role in the Pathogenicity of LeukemiaSemantic proximity Read ↗

A functional inflammasome activation assaydifferentiates patients with pathogenic NLRP3mutations and symptomatic patients with lowpenetrance variantsSemantic proximity Read ↗

Identification of the Q969R gain-of-function polymorphism in the gene encoding porcine NLRP3 and its distribution in pigs of Asian and European origin.Semantic proximity Read ↗

NLRP3 leucine-rich repeats control induced and spontaneous inflammasome activation in cryopyrin-associated periodic syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.