Article
Evidence of antagonistic regulation of restart from G(1) delay in response to osmotic stress by the Hog1 and Whi3 in budding yeast.
Bioscience, biotechnology, and biochemistry - 1 Jan 2013
Mizunuma Masaki, Ogawa Takafumi, Koyama Tetsuya, Shitamukai Atsunori, Tsubakiyama Ryohei, Komaruyama Tadamasa, Yamaguchi Toshinaga, Kume Kazunori, Hirata Dai
Abstract excerpt
Hog1 of Saccharomyces cerevisiae is activated by hyperosmotic stress, and this leads to cell-cycle delay in G1, but the mechanism by which cells restart from G1 delay remains elusive. We found that Whi3, a negative regulator of G1 cyclin, counteracted Hog1 in the restart from G1 delay caused by osmotic stress. We have found that phosphorylation of Ser-568 in Whi3 by RAS/cAMP-dependent protein kinase (PKA) plays...
Topics
- Cyclins
- G1 Phase Cell Cycle Checkpoints
- Mitogen-Activated Protein Kinases
- Mutation
- Osmotic Pressure
- RNA-Binding Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Up-Regulation