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Article

MRN Complex and Cancer Risk: Old Bottles, New Wine.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2021

Elkholi Islam E, Foulkes William D, Rivera Barbara

Abstract excerpt

The MRN complex, composed of MRE11A, RAD50, and NBN, mediates vital molecular functions to maintain genomic stability and hence protect against related disorders. Germline mutations in the MRN genes predispose to three different syndromes: ataxia-telangiectasia-like disorder (MRE11A deficiency), Nijmegen breakage syndrome (NBS; NBN deficiency), and NBS-like disorder (RAD50 deficiency). The potential cancer...

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Identifiers

PMID: 34261697
DOI: 10.1158/1078-0432.CCR-21-1509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MRN Complex and Cancer Risk: Old Bottles, New Wine.PMID 34261697Read ↗

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The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer.Semantic proximity Read ↗

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