Article
Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology - 1 Jan 2000
Tuunanen Helena, Kuusisto Johanna, Toikka Jyri, Jääskeläinen Pertti, Marjamäki Päivi, Peuhkurinen Keijo, Viljanen Tapio, Sipola Petri, Stolen Kira Q, Hannukainen Jarna, Nuutila Pirjo, Laakso Markku, Knuuti Juhani
Abstract excerpt
BACKGROUND: The relationship between myocardial metabolic changes and the severity of left ventricular (LV) hypertrophy in patients with hypertrophic cardiomyopathy (HCM) is largely unknown. We characterized metabolic abnormalities in patients with a genetically identical cause for HCM but with variable LV hypertrophy. METHODS AND RESULTS: Eight patients with HCM attributable to the Asp175Asn mutation in the...
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