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Article

SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo.

Journal of molecular and cellular cardiology - 1 Nov 2013

Paul Jonathan D, Coulombe Kareen L K, Toth Peter T, Zhang Yanmin, Marsboom Glenn, Bindokas Vytas P, Smith David W, Murry Charles E, Rehman Jalees

Abstract excerpt

Successful implantation and long-term survival of engineered tissue grafts hinges on adequate vascularization of the implant. Endothelial cells are essential for patterning vascular structures, but they require supportive mural cells such as pericytes/mesenchymal stem cells (MSCs) to generate stable, functional blood vessels. While there is evidence that the angiogenic effect of MSCs is mediated via the secretion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24090675
DOI: 10.1016/j.yjmcc.2013.09.005
PMCID: PMC3885335

Genes

SLIT3
ROBO4
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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