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Article

Angiogenic Mechanisms of Human CD34+ Stem Cell Exosomes in the Repair of Ischemic Hindlimb.

Circulation research - 28 Apr 2017

Mathiyalagan Prabhu, Liang Yaxuan, Kim David, Misener Sol, Thorne Tina, Kamide Christine E, Klyachko Ekaterina, Losordo Douglas W, Hajjar Roger J, Sahoo Susmita

Abstract excerpt

RATIONALE: Paracrine secretions seem to mediate therapeutic effects of human CD34+ stem cells locally transplanted in patients with myocardial and critical limb ischemia and in animal models. Earlier, we had discovered that paracrine secretion from human CD34+ cells contains proangiogenic, membrane-bound nanovesicles called exosomes (CD34Exo). OBJECTIVE: Here, we investigated the mechanisms of CD34Exo-mediated...

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Share to Angiogenic Proteins
Share to Endothelial Progenitor Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exosomes

Share to Hindlimb

Share to Ischemia

Share to Paracrine Communication

Share to Recovery of Function

Share to Regional Blood Flow

Source

Open in PubMed Open full text

Identifiers

PMID: 28298297
DOI: 10.1161/CIRCRESAHA.116.310557
PMCID: PMC5420547

Genes

MMP9
SPRED1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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