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Article

Evaluation of allele frequency estimation using pooled sequencing data simulation.

TheScientificWorldJournal - 1 Jan 2013

Guo Yan, Samuels David C, Li Jiang, Clark Travis, Li Chung-I, Shyr Yu

Abstract excerpt

Next-generation sequencing (NGS) technology has provided researchers with opportunities to study the genome in unprecedented detail. In particular, NGS is applied to disease association studies. Unlike genotyping chips, NGS is not limited to a fixed set of SNPs. Prices for NGS are now comparable to the SNP chip, although for large studies the cost can be substantial. Pooling techniques are often used to reduce...

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Computer Simulation
Databases, Nucleic Acid
Exome
Gene Frequency
Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23476151
DOI: 10.1155/2013/895496
PMCID: PMC3582166

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