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Article

Polyalanine repeat polymorphism in RUNX2 is associated with site-specific fracture in post-menopausal females.

PloS one - 1 Jan 2013

Morrison Nigel A, Stephens Alexandre S, Osato Motomi, Pasco Julie A, Fozzard Nicolette, Stein Gary S, Polly Patsie, Griffiths Lyn R, Nicholson Geoff C

Abstract excerpt

Runt related transcription factor 2 (RUNX2) is a key regulator of osteoblast differentiation. Several variations within the RUNX2 gene have been found to be associated with significant changes in BMD, which is a major risk factor for fracture. In this study we report that an 18 bp deletion within the polyalanine tract (17A>11A) of RUNX2 is significantly associated with fracture. Carriers of the 11A allele were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24086263
DOI: 10.1371/journal.pone.0072740
PMCID: PMC3781152

Genes

RUNX2

Provenance

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