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Article

Polymorphisms in the Osteoprotegerin Gene Are Associated With Osteoporotic Fractures

1 Jul 2002

Abstract excerpt

Osteoprotegerin (OPG) is a soluble receptor for RANKL and therefore a competitive inhibitor of osteoclast differentiation and activity. With this key role in the control of resorptive activity, we found that OPG is a candidate gene for genetic control of bone mass. We examined the promoter and the five exons with surrounding intron sequences of the OPG gene for polymorphisms in 50 normal patients and 50 patients...

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Identifiers

PMID: 12096838
DOI: 10.1359/jbmr.2002.17.7.1245

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Research trail→

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Polymorphisms in the Osteoprotegerin Gene Are Associated With Osteoporotic FracturesPMID 12096838Read ↗

Common Variants of the OPG gene Are Associated with Osteoporosis Risk: A Meta-Analysis.Semantic proximity Read ↗

No associations between OPG gene polymorphisms or serum levels and measures of osteoporosis in elderly Australian women.Semantic proximity Read ↗

Association of the osteoprotegerin gene polymorphisms with bone mineral density in postmenopausal women.Semantic proximity Read ↗

Associations of osteoprotegerin (OPG) TNFRSF11B gene polymorphisms with risk of fractures in older adult populations: meta-analysis of genetic and genome-wide association studies.Semantic proximity Read ↗

Association between seven common OPG genetic polymorphisms and osteoporosis risk: a meta-analysis.Semantic proximity Read ↗

The effect of A163G polymorphism in the osteoprotegerin gene on osteoporosis related traits in Slovak postmenopausal women.Semantic proximity Read ↗

Sequence variations in the osteoprotegerin gene promoter in patients with postmenopausal osteoporosis.Semantic proximity Read ↗

Significant associations between the A163G and G1181C polymorphisms of the osteoprotegerin gene and risk of osteoporosis, especially in postmenopausal women: a meta-analysis.Semantic proximity Read ↗

Associations between osteoprotegerin polymorphisms and bone mineral density: a meta-analysis.Semantic proximity Read ↗

Osteoprotegerin Lys3Asn polymorphism and the risk of fracture in older women.Semantic proximity Read ↗

[Polymorphism of osteoprotegerin gene and osteoporosis in postmenopausal women].Semantic proximity Read ↗

Single nucleotide polymorphisms in the human gene for osteoprotegerin are not related to bone mineral density or fracture in elderly women.Semantic proximity Read ↗

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