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Article

Polymorphisms in BMP4 and FGFR1 genes are associated with fracture non-union.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Dec 2013

Guimarães João Matheus, Guimarães Isabel Cristina do Val, Duarte Maria Eugenia Leite, Vieira Thays, Vianna Verônica Fernandes, Fernandes Marco Bernardo Cury, Vieira Alexandre Rezende, Casado Priscila Ladeira

Abstract excerpt

Fracture healing is a complex process influenced by a multitude of factors and expression of several thousand genes. Polymorphisms in these genes can lead to an extended healing process and explain why certain patients are more susceptible to develop non-union. A total of 16 SNPs within five genes involved in bone repair pathogenesis (FAM5C, BMP4, FGF3, FGF10, and FGFR1) were investigated in 167 patients with...

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Aged
Bone Morphogenetic Protein 4
BMP4 gene
FGF10 gene
FGFR1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Receptor, Fibroblast Growth Factor, Type 1

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Identifiers

PMID: 23939983
DOI: 10.1002/jor.22455

Genes

BMP4
FGFR1
FGF10
FGF3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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