Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Self-inactivating Gammaretroviral Vectors for Gene Therapy of X-linked Severe Combined Immunodeficiency

8 Jan 2008

Abstract excerpt

Gene therapy for X-linked severe combined immunodeficiency (SCID-X1) has proven highly effective for long-term restoration of immunity in human subjects. However, the development of lymphoproliferative complications due to dysregulated proto-oncogene expression has underlined the necessity for developing safer vector systems. To reduce the potential for insertional mutagenesis, we have evaluated the efficacy of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to RNA Interference and Gene Delivery
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18180772
DOI: 10.1038/sj.mt.6300393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Self-inactivating Gammaretroviral Vectors for Gene Therapy of X-linked Severe Combined ImmunodeficiencyPMID 18180772Read ↗

Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?Semantic proximity Read ↗

Clinical Applications of Gene Therapy for Primary ImmunodeficienciesSemantic proximity Read ↗

A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.Semantic proximity Read ↗

Preclinical Development of a Lentiviral Vector for Gene Therapy of X-Linked Severe Combined ImmunodeficiencySemantic proximity Read ↗

Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and γc OverexpressionSemantic proximity Read ↗

Immune Reconstitution After Gene Therapy Approaches in Patients With X-Linked Severe Combined Immunodeficiency DiseaseSemantic proximity Read ↗

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease.Semantic proximity Read ↗

A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cellsSemantic proximity Read ↗

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivoSemantic proximity Read ↗

Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral VectorsSemantic proximity Read ↗

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector.Semantic proximity Read ↗

Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.