Article
Effect of prenatal hypoxia in transgenic mouse models of preeclampsia and fetal growth restriction.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Apr 2014
Rueda-Clausen C F, Stanley J L, Thambiraj D F, Poudel R, Davidge S T, Baker P N
Abstract excerpt
Mice lacking endothelial nitric oxide synthase (eNOS(-)(/-)) or catechol-O-methyl transferase (COMT(-/-)) exhibit a preeclampsia-like phenotype and fetal growth restriction. We hypothesized that a hypoxic insult would result in a more severe phenotype. Pregnant eNOS(-/-), COMT(-/-) and control (C57BL/6J) mice were randomized to hypoxic (10.5% O(2)) or normal conditions (20.9% O(2)) from gestational day 10.5 to...
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