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Article

Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice

4 Sept 2018

Abstract excerpt

Preeclampsia remains a clinical challenge due to its poorly understood pathogenesis. A prevailing notion is that increased placental production of soluble fms-like tyrosine kinase-1 (sFlt-1) causes the maternal syndrome by inhibiting proangiogenic placental growth factor (PlGF) and VEGF. However, the significance of PlGF suppression in preeclampsia is uncertain. To test whether preeclampsia results from the...

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PMID: 30179860
DOI: 10.1172/jci99026

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