Article
Bulky DNA Adducts, Tobacco Smoking, Genetic Susceptibility, and Lung Cancer Risk.
Advances in clinical chemistry - 1 Jan 2000
Munnia Armelle, Giese Roger W, Polvani Simone, Galli Andrea, Cellai Filippo, Peluso Marco E M
Abstract excerpt
The generation of bulky DNA adducts consists of conjugates formed between large reactive electrophiles and DNA-binding sites. The term "bulky DNA adducts" comes from early experiments that employed a 32P-DNA postlabeling approach. This technique has long been used to elucidate the association between adducts and carcinogen exposure in tobacco smoke studies and assess the predictive value of adducts in cancer...
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