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Article

DNA adducts and combinations of multiple lung cancer at-risk alleles in environmentally exposed and smoking subjects.

Environmental and molecular mutagenesis - 1 Jul 2013

Peluso Marco E M, Munnia Armelle, Srivatanakul Petcharin, Jedpiyawongse Adisorn, Sangrajrang Suleeporn, Ceppi Marcello, Godschalk Roger W L, van Schooten Frederik J, Boffetta Paolo

Abstract excerpt

Interindividual variation in DNA adduct levels in individuals exposed to similar amounts of environmental carcinogens may be due to genetic variability. We analysed the influence of genes involved in determining/modifying DNA damage, including microsomal epoxide hydrolase1 (EPHX1) His139Arg, N-acetyl-transferase, NAD(P)H:quinone oxidoreductase1 (NQO1) Pro187Ser, manganese superoxide dismutase2 (MnSOD2) Val16Ala,...

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Source

Identifiers

PMID: 23797975
DOI: 10.1002/em.21788

Genes

NQO1
EPHX1

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