Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proliferative phenotype of pulmonary microvascular endothelial cells plays a critical role in the overexpression of CTGF in the bleomycin-injured rat.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Jan 2014

Yan Lin-Feng, Wei Ya-Ning, Nan Hai-Yan, Yin Qian, Qin Yue, Zhao Xin, Chen Bao-Ying, Zhao Ge, Wei Jing-Guo, Cui Guang-Bin

Abstract excerpt

The pathogenesis of idiopathic pulmonary fibrosis (IPF) is not very clear, with evidence for the involvement of both inflammation and aberrant vascular remodeling (associated with angiogenesis). Pulmonary microvascular endothelial cells (PMVECs), which play a major role in inflammation, secrete cytokines that promote the transformation and collagen synthesis of fibroblasts. Moreover, angiogenesis is characterized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic
Share to Bleomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connective Tissue Growth Factor

Share to Endothelial Cells

Share to Enzyme-Linked Immunosorbent Assay

Share to Idiopathic Pulmonary Fibrosis

Share to Microscopy, Confocal

Share to Rats, Sprague-Dawley

Source

Identifiers

PMID: 24083993
DOI: 10.1016/j.etp.2013.08.004

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proliferative phenotype of pulmonary microvascular endothelial cells plays a critical role in the overexpression of CTGF in the bleomycin-injured rat.PMID 24083993Read ↗

Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension.Semantic proximity Read ↗

Endothelial Cells Recruit Macrophages and Contribute to a Fibrotic Milieu in Bleomycin Lung InjurySemantic proximity Read ↗

Qualitative Rather than Quantitative Changes Are Hallmarks of Fibroblasts in Bleomycin-Induced Pulmonary FibrosisSemantic proximity Read ↗

Quercetin regulates pulmonary vascular remodeling in pulmonary hypertension through TGF-β1-Smad2/3 pathwaySemantic proximity Read ↗

Time-dependent phenotypic and contractile changes of pulmonary artery in chronic hypoxia-induced pulmonary hypertension.Semantic proximity Read ↗

An essential role for CCAAT/enhancer binding protein beta in bleomycin-induced pulmonary fibrosis.Semantic proximity Read ↗

Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension.Semantic proximity Read ↗

Keratinocyte growth factor gene transduction ameliorates pulmonary fibrosis induced by bleomycin in mice.Semantic proximity Read ↗

Low-dose fluvastatin reverses the hypoxic pulmonary adventitial fibroblast phenotype in experimental pulmonary hypertension.Semantic proximity Read ↗

The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system.Semantic proximity Read ↗

Annexin A1 protein regulates the expression of PMVEC cytoskeletal proteins in CBDL rat serum-induced pulmonary microvascular remodeling.Semantic proximity Read ↗

Functional Improvement and Regression of Medial Hypertrophy in the Remodeled Pulmonary Artery after Correction of Systemic Left-to-Right Shunt.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.