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Article

A novel Sit4 phosphatase complex is involved in the response to ceramide stress in yeast.

Oxidative medicine and cellular longevity - 1 Jan 2013

Woodacre Alexandra, Lone Museer A, Jablonowski Daniel, Schneiter Roger, Giorgini Flaviano, Schaffrath Raffael

Abstract excerpt

Ceramide is a building block for complex sphingolipids in the plasma membrane, but it also plays a significant role in secondary signalling pathways regulating cell proliferation and apoptosis in response to stress. Ceramide activated protein phosphatase activity has been previously observed in association with the Sit4 protein phosphatase. Here we find that sit4Δ mutants have decreased ceramide levels and...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spectrometry, Mass, Electrospray Ionization

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Source

Open in PubMed Open full text

Identifiers

PMID: 24082981
DOI: 10.1155/2013/129645
PMCID: PMC3777123

Genes

KTI12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel Sit4 phosphatase complex is involved in the response to ceramide stress in yeast.PMID 24082981Read ↗

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