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Article

Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46.

Science (New York, N.Y.) - 2 Mar 1990

Sachs A B, Davis R W

Abstract excerpt

Cold-sensitive mutations in the SPB genes (spb1-spb7) of Saccharomyces cerevisiae suppress the inhibition of translation initiation resulting from deletion of the poly(A)-binding protein gene (PAB1). The SPB4 protein belongs to a family of adenosine triphosphate (ATP)-dependent RNA helicases. The aberrant production of 25S ribosomal RNA (rRNA) occurring in spb4-1 mutants or the deletion of SPB2 (RPL46) permits...

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PMID: 2408148
DOI: 10.1126/science.2408148

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