Article
ThrR, a DNA-binding transcription factor involved in controlling threonine biosynthesis in Bacillus subtilis.
Molecular microbiology - 1 Sept 2016
Rosenberg Jonathan, Müller Peter, Lentes Sabine, Thiele Martin J, Zeigler Daniel R, Tödter Dominik, Paulus Henry, Brantl Sabine, Stülke Jörg, Commichau Fabian M
Abstract excerpt
The threonine dehydratase IlvA is part of the isoleucine biosynthesis pathway in the Gram-positive model bacterium Bacillus subtilis. Consequently, deletion of ilvA causes isoleucine auxotrophy. It has been reported that ilvA pseudo-revertants having a derepressed hom-thrCB operon appear in the presence of threonine. Here we have characterized two classes of ilvA pseudo-revertants. In the first class the...
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