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Article

The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure.

Developmental biology - 1 Jun 2007

Zohn Irene E, Anderson Kathryn V, Niswander Lee

Abstract excerpt

Closure of the cranial neural tube depends on normal development of the head mesenchyme. Homozygous-mutant embryos for the ENU-induced open mind (opm) mutation exhibit exencephaly associated with defects in head mesenchyme development and dorsal-lateral hinge point formation. The head mesenchyme in opm mutant embryos is denser than in wildtype embryos and displays an abnormal cellular organization. Since cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17442300
DOI: 10.1016/j.ydbio.2007.03.018
PMCID: PMC2730518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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