Article
The Role of Matrix Metalloproteinases Polymorphisms in Age-Related Macular Degeneration.
Ophthalmic genetics - 1 Jun 2015
Liutkeviciene Rasa, Lesauskaite Vaiva, Sinkunaite-Marsalkiene Giedre, Zaliuniene Dalia, Zaliaduonyte-Peksiene Diana, Mizariene Vaida, Gustiene Olivija, Jasinskas Vytautas, Jariene Giedre, Tamosiunas Abdonas
Abstract excerpt
BACKGROUND: Matrix metalloproteinases (MMP) are responsible for the degradation of extracellular matrix components and play an important role in the physiological and pathological remodeling of tissues. PURPOSE: To assess the impact of MMP-2 Rs2285053 (C->T), MMP-3 Rs3025039 (5A->6A), and MMP-9 Rs3918242 (C->T) single nucleotide polymorphism on the development of early age-related macular degeneration (AMD)....
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