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Article

Increased pro-MMP9 plasma levels are associated with neovascular age-related macular degeneration and with the risk allele of rs142450006 near MMP9.

Molecular vision - 1 Jan 2021

Lauwen Susette, Lefeber Dirk J, Fauser Sascha, Hoyng Carel B, den Hollander Anneke I

Abstract excerpt

Purpose: To evaluate the plasma levels of matrix metalloproteinase 9 (MMP9) and tissue inhibitors of metalloproteinase 3 (TIMP3) in neovascular age-related macular degeneration (nAMD) patients compared to controls, and to explore the potential effect of AMD-associated genetic variants on MMP9 and TIMP3 protein levels. Methods: nAMD and control patients were selected from the European Genetic Database (EUGENDA)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33907369
PMCID: PMC8056465

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