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Article

The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers.

Molecular cancer - 30 Sept 2013

Ziółkowska-Suchanek Iwona, Mosor Maria, Wierzbicka Małgorzata, Rydzanicz Małgorzata, Baranowska Marta, Nowak Jerzy

Abstract excerpt

BACKGROUND: The members of MRE11/RAD50/NBN (MRN) protein complex participates in DNA double-strand break repair and DNA-damage checkpoint activation. We have previously shown that the p.I171V NBN gene mutation may contribute to the development of laryngeal cancer. This study tested the hypothesis that variants of the MRE11 and RAD50 genes, previously described as cancer risk factors, predispose to increased...

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Source

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Identifiers

PMID: 24079363
DOI: 10.1186/1476-4598-12-113
PMCID: PMC3856607

Genes

RAD50
MRE11
NBN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers.PMID 24079363Read ↗

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