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Article

Germline pathogenic variants in the MRE11, RAD50, and NBN (MRN) genes in cancer predisposition: A systematic review and meta-analysis.

International journal of cancer - 1 Nov 2024

Stastna Barbora, Dolezalova Tatana, Matejkova Katerina, Nemcova Barbora, Zemankova Petra, Janatova Marketa, Kleiblova Petra, Soukupova Jana, Kleibl Zdenek

Abstract excerpt

The MRE11, RAD50, and NBN genes encode the MRN complex sensing DNA breaks and directing their repair. While carriers of biallelic germline pathogenic variants (gPV) develop rare chromosomal instability syndromes, the cancer risk in heterozygotes remains controversial. We performed a systematic review and meta-analysis of 53 studies in patients with different cancer diagnoses to better understand the cancer risk....

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Source

Identifiers

PMID: 38924040
DOI: 10.1002/ijc.35066

Genes

MRE11
NBN
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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