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Article

The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer.

Mutation research - 1 Jan 2000

Dzikiewicz-Krawczyk Agnieszka

Abstract excerpt

The MRN protein complex, consisting of MRE1, RAD50 and NBS1, plays a crucial role in sensing DNA double-strand breaks (DSBs), and it is involved in cell cycle control. This makes the MRN complex an important guard of genome stability. Hypomorphic mutations in NBS1 result in the Nijmegen breakage...

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Source

Identifiers

PMID: 18606567
DOI: 10.1016/j.mrrev.2008.05.005

Genes

RAD50
MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18606567-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer.PMID 18606567Read ↗

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MRN Complex and Cancer Risk: Old Bottles, New Wine.Semantic proximity Read ↗

Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.Semantic proximity Read ↗

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Human RAD50 deficiency: Confirmation of a distinctive phenotype.Semantic proximity Read ↗

657del5 mutation in the gene for Nijmegen breakage syndrome (NBS1) in a cohort of Russian children with lymphoid tissue malignancies and controls.Semantic proximity Read ↗

Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair.Semantic proximity Read ↗

MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal CancerSemantic proximity Read ↗

Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer CellsSemantic proximity Read ↗

Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.Semantic proximity Read ↗

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