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Article

Computational methods for high-throughput comparative analyses of natural microbial communities.

Methods in enzymology - 1 Jan 2013

Preheim Sarah P, Perrotta Allison R, Friedman Jonathan, Smilie Chris, Brito Ilana, Smith Mark B, Alm Eric

Abstract excerpt

One of the most widely employed methods in metagenomics is the amplification and sequencing of the highly conserved ribosomal RNA (rRNA) genes from organisms in complex microbial communities. rRNA surveys, typically using the 16S rRNA gene for prokaryotic identification, provide information about the total diversity and taxonomic affiliation of organisms present in a sample. Greatly enhanced by high-throughput...

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PMID: 24060130
DOI: 10.1016/B978-0-12-407863-5.00018-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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