Article
Induced pluripotent stem cells as a tool for gaining new insights into Fanconi anemia.
Cell cycle (Georgetown, Tex.) - 15 Aug 2012
Müller Lars U W, Schlaeger Thorsten M, DeVine Alexander L, Williams David A
Abstract excerpt
Induced pluripotent stem cells (iPSC) hold significant promise for advancing biomedical research. In the case of monogenic diseases, patient-iPSC and their derivatives contain the disease-causing mutation, suggesting the possibility of recapitulating salient disease features in vitro. Fanconi anemia (FA) is the most common inherited bone marrow failure syndrome. The etiology of bone marrow failure in FA remains...
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