Article
Cloning of an alternate form of vascular cell adhesion molecule-1 (VCAM1).
The Journal of biological chemistry - 15 Apr 1991
Hession C, Tizard R, Vassallo C, Schiffer S B, Goff D, Moy P, Chi-Rosso G, Luhowskyj S, Lobb R, Osborn L
Abstract excerpt
Vascular cell adhesion molecule-1 (VCAM1) of the Ig superfamily is induced by the inflammatory cytokines interleukin-1 and tumor necrosis factor on human umbilical vein endothelial cells (HUVECs). It binds to mononuclear leukocytes via the integrin VLA-4. We have cloned and expressed a cDNA encoding a new form of human VCAM1 containing an additional Ig homologous domain inserted between the third and fourth...
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