Article
Association between polymorphisms in the biometabolism genes CYP1A1, GSTM1, GSTT1 and GSTP1 in bladder cancer.
Clinical and experimental medicine - 1 Mar 2009
Grando João Paulo Souto, Kuasne Hellen, Losi-Guembarovski Roberta, Sant'ana Rodrigues Iara, Matsuda Henrique Mitsu, Fuganti Paulo Emílio, Gregório Emerson Pereira, Júnior Farid Libos, de Menezes Rodrigo Paes, de Freitas Rodrigues Marco Aurélio, de Syllos Cólus Ilce Mara
Abstract excerpt
Numerous enzymes, including Cytochrome P450s (phase I) and Glutathione-S-transferases (phase II), are involved in the metabolic activation and detoxification of carcinogens. Epidemiological studies have consistently demonstrated that bladder cancer is strongly associated with cigarette smoking, a...
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