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Article

Type 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype.

American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2009

Zhu Bing, Zhang Li, Alexeyev Mikhail, Alvarez Diego F, Strada Samuel J, Stevens Troy

Abstract excerpt

Type 5 phosphodiesterase (PDE5) inhibitors increase endothelial cell cGMP and promote angiogenesis. However, not all endothelial cell phenotypes express PDE5. Indeed, whereas conduit endothelial cells express PDE5, microvascular endothelial cells do not express this enzyme, and they are rapidly angiogenic. These findings bring into question whether PDE5 activity is a critical determinant of the endothelial cell...

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Identifiers

PMID: 19028977
DOI: 10.1152/ajplung.90474.2008
PMCID: PMC2643995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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