Article
Vitamin D(3) and analogues modulate the expression of CSF-1 and its receptor in human dendritic cells.
Biochemical and biophysical research communications - 11 Oct 2002
Zhu Kejian, Gläser Regine, Mrowietz Ulrich
Abstract excerpt
The active vitamin D(3)-metabolite 1,25(OH)(2)D(3) inhibits the interleukin 4/granulocyte-macrophage colony-stimulating factor (IL-4/GM-CSF)-induced differentiation of human monocytes into dendritic cells without altering survival. Colony-stimulating factor 1 (CSF-1) is an important survival factor for cells of the monocytic lineage. We therefore investigated whether the inhibitory activity of 1,25(OH)(2)D(3) is...
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