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Article

Common genetic variation near MC4R has a sex-specific impact on human brain structure and eating behavior.

PloS one - 1 Jan 2013

Horstmann Annette, Kovacs Peter, Kabisch Stefan, Boettcher Yvonne, Schloegl Haiko, Tönjes Anke, Stumvoll Michael, Pleger Burkhard, Villringer Arno

Abstract excerpt

Obesity is associated with genetic and environmental factors but the underlying mechanisms remain poorly understood. Recent genome-wide association studies (GWAS) identified obesity- and type 2 diabetes-associated genetic variants located within or near genes that modulate brain activity and development. Among the top hits is rs17782313 near MC4R, encoding for the melanocortin-4-receptor, which is expressed in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24066140
DOI: 10.1371/journal.pone.0074362
PMCID: PMC3774636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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