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Article

Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines.

Science signaling - 24 Sept 2013

Niepel Mario, Hafner Marc, Pace Emily A, Chung Mirra, Chai Diana H, Zhou Lili, Schoeberl Birgit, Sorger Peter K

Abstract excerpt

Identifying factors responsible for variation in drug response is essential for the effective use of targeted therapeutics. We profiled signaling pathway activity in a collection of breast cancer cell lines before and after stimulation with physiologically relevant ligands, which revealed the variability in network activity among cells of known genotype and molecular subtype. Despite the receptor-based...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24065145
DOI: 10.1126/scisignal.2004379
PMCID: PMC3845839

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