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Subtype and pathway specific responses to anticancer compounds in breast cancer

14 Oct 2011

Abstract excerpt

Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations between molecular subtypes, pathways, and drug...

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PMID: 22003129
DOI: 10.1073/pnas.1018854108

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