Article
Polymorphisms in nitric oxide synthase and endothelin genes among children with obstructive sleep apnea.
BMC medical genomics - 6 Sept 2013
Chatsuriyawong Siriporn, Gozal David, Kheirandish-Gozal Leila, Bhattacharjee Rakesh, Khalyfa Ahamed A, Wang Yang, Sukhumsirichart Wasana, Khalyfa Abdelnaby
Abstract excerpt
BACKGROUND: Obstructive sleep apnea (OSA) is associated with adverse and interdependent cognitive and cardiovascular consequences. Increasing evidence suggests that nitric oxide synthase (NOS) and endothelin family (EDN) genes underlie mechanistic aspects of OSA-associated morbidities. We aimed to identify single nucleotide polymorphisms (SNPs) in the NOS family (3 isoforms), and EDN family (3 isoforms) to...
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