Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi Step Selection in Ig H Chains is Initially Focused on CDR3 and Then on Other CDR Regions

1 Jan 2013

Abstract excerpt

AFFINITY MATURATION OCCURS THROUGH TWO SELECTION PROCESSES: the choice of appropriate clones (clonal selection), and the internal evolution within clones, induced by somatic hyper-mutations, where high affinity mutants are selected for. When a final population of immunoglobulin sequences is observed, the genetic composition of this population is affected by a combination of these two processes. Different immune...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24062742
DOI: 10.3389/fimmu.2013.00274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi Step Selection in Ig H Chains is Initially Focused on CDR3 and Then on Other CDR RegionsPMID 24062742Read ↗

The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales.Semantic proximity Read ↗

Estimate of within population incremental selection through branch imbalance in lineage trees.Semantic proximity Read ↗

Detecting selection in immunoglobulin sequencesSemantic proximity Read ↗

Age- and tissue-specific differences in human germinal center B cell selection revealed by analysis of IgVH gene hypermutation and lineage trees.Semantic proximity Read ↗

Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases.Semantic proximity Read ↗

Affinity maturation of B cells involves not only a few but a whole spectrum of relevant mutations.Semantic proximity Read ↗

Ig gene sequences in the study of clonality.Semantic proximity Read ↗

Soma‐to‐germline feedback is implied by the extreme polymorphism at IGHV relative to MHCSemantic proximity Read ↗

Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection.Semantic proximity Read ↗

Antigen-driven selection in germinal centers as reflected by the shape characteristics of immunoglobulin gene lineage trees: A large-scale simulation studySemantic proximity Read ↗

Strong intrinsic biases towards mutation and conservation of bases in human IgV<sub>H</sub> genes during somatic hypermutation prevent statistical analysis of antigen selectionSemantic proximity Read ↗

The dynamics of germinal centre selection as measured by graph-theoretical analysis of mutational lineage trees.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.