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Comprehensive analysis of PTEN status in Sézary syndrome

24 Sept 2013

Abstract excerpt

Sézary syndrome (SS) is an incurable leukemic variant of cutaneous T-cell lymphoma characterized by recurrent chromosomal alterations, among which, chromosome 10q deletion is very frequent. In this study, we investigated the PTEN status, on locus 10q23, in 44 SS patients; our findings show that PTEN is deleted in 36% of SS cases, whereas PTEN downregulation is observed in almost all of the samples evaluated by...

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PMID: 24062018
DOI: 10.1182/blood-2013-06-510578

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